Association of the MAPT locus with Parkinson’s disease
Identifieur interne : 000804 ( Main/Exploration ); précédent : 000803; suivant : 000805Association of the MAPT locus with Parkinson’s disease
Auteurs : C. Wider [États-Unis] ; C. Vilari O-Güell [États-Unis] ; B. Jasinska-Myga [États-Unis, Pologne] ; M. G. Heckman [États-Unis] ; A. I. Soto-Ortolaza [États-Unis] ; S. A. Cobb [États-Unis] ; J. O. Aasly [Norvège] ; J. M. Gibson [Irlande (pays)] ; T. Lynch [Irlande (pays)] ; R. J. Uitti [États-Unis] ; Z. K. Wszolek [États-Unis] ; M. J. Farrer [États-Unis] ; O. A. Ross [États-Unis]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2010-03.
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- KwdEn :
Abstract
Background and purpose: Whilst an association between the tau gene (MAPT)‐containing H1 haplotype and supranuclear gaze palsy (PSP) has long been recognized, the effect of H1 on risk for Parkinson’s disease (PD) has remained more contentious. Methods: Herein, we examined the association of H1 and PD in three Caucasian PD patient–control series from Ireland, Norway, and the US (combined: n = 2619), by genotyping two H1/H2 single nucleotide polymorphisms (SNPs) in MAPT (rs1052553) and in the Saitohin gene (rs62063857) and one H1‐specific SNP (rs242557). Results: We identified a significant association between H1/H2 and risk of PD (rs1052553 OR: 1.43, CI: 1.23–1.64; rs62063857 OR: 1.45, CI: 1.27–1.67), but no effect of the H1‐specific SNP rs242557 (OR: 0.92, CI: 0.82–1.03). Conclusions: Our findings show that the H1 haplotype is a significant risk factor for PD. However, one H1‐specific SNP (rs242557) previously implicated in PSP did not alter the risk of PD, indicating that distinct H1 sub‐haplotypes probably drive the associations with PD and PSP.
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DOI: 10.1111/j.1468-1331.2009.02847.x
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Methods: Herein, we examined the association of H1 and PD in three Caucasian PD patient–control series from Ireland, Norway, and the US (combined: n = 2619), by genotyping two H1/H2 single nucleotide polymorphisms (SNPs) in MAPT (rs1052553) and in the Saitohin gene (rs62063857) and one H1‐specific SNP (rs242557). Results: We identified a significant association between H1/H2 and risk of PD (rs1052553 OR: 1.43, CI: 1.23–1.64; rs62063857 OR: 1.45, CI: 1.27–1.67), but no effect of the H1‐specific SNP rs242557 (OR: 0.92, CI: 0.82–1.03). Conclusions: Our findings show that the H1 haplotype is a significant risk factor for PD. However, one H1‐specific SNP (rs242557) previously implicated in PSP did not alter the risk of PD, indicating that distinct H1 sub‐haplotypes probably drive the associations with PD and PSP.</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li><li>Norvège</li><li>Pologne</li><li>États-Unis</li></country><region><li>Floride</li><li>Trøndelag</li></region><settlement><li>Trondheim</li></settlement></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Wider, C" sort="Wider, C" uniqKey="Wider C" first="C." last="Wider">C. Wider</name></region><name sortKey="Cobb, S A" sort="Cobb, S A" uniqKey="Cobb S" first="S. A." last="Cobb">S. A. Cobb</name><name sortKey="Farrer, M J" sort="Farrer, M J" uniqKey="Farrer M" first="M. J." last="Farrer">M. J. Farrer</name><name sortKey="Heckman, M G" sort="Heckman, M G" uniqKey="Heckman M" first="M. G." last="Heckman">M. G. 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